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Goldman: Cecil Medicine, 23rd ed. Copyright © 2007 Saunders, An Imprint of Elsevier SUGGESTED READINGS Linnik MD, Hu JZ, Heilbrunn KR, et al: Relationship between anti-double-stranded DNA antibodies and exacerbation of renal disease in patients with systemic lupus erythematosus.  Arthritis Rheum  2005; 52:1129-1137.Increases in anti-DNA antibodies were associated with flares of renal disease Manzi S, Navratil JS, Ruffing MJ, et al: Measurement of erythrocyte C4d […]

Goldman: Cecil Medicine, 23rd ed. Copyright © 2007 Saunders, An Imprint of Elsevier LABORATORY EVALUATION OF MUSCULOSKELETAL DISEASE The most common presentation of musculoskeletal disease is pain in and around a joint in association with functional impairment. Collectively, diseases causing joint symptoms are called arthritis, implying inflammation. The extent of inflammation in these diseases varies […]

Goldman: Cecil Medicine, 23rd ed. Copyright © 2007 Saunders, An Imprint of Elsevier MAGNETIC RESONANCE IMAGING The demands of imaging are increased in this age of effective therapy to halt the progression of arthropathy. Over the last two decades, MRI has become the imaging modality of choice for evaluation of joint soft tissue, marrow structures, […]

Goldman: Cecil Medicine, 23rd ed. Copyright © 2007 Saunders, An Imprint of Elsevier SUGGESTED READINGS Aberer W, Bircher A, Romano A, et al: Drug provocation testing in the diagnosis of drug hypersensitivity reactions: General considerations.  Allergy  2003; 58:854-863.An overview of this approach Brockow K, Christiansen C, Kanny G, et al: Management of hypersensitivity reactions to iodinated contrast media.  Allergy  2005; 60:150-158.A comprehensive review Gruchalla RS: Drug allergy.  J […]

Goldman: Cecil Medicine, 23rd ed. Copyright © 2007 Saunders, An Imprint of Elsevier SUGGESTED READINGS Akin C, Metcalfe DD: Systemic mastocytosis.  Annu Rev Med  2004; 55:419.A concise review Akin C, Metcalfe DD: The biology of Kit in disease and the application of pharmacogenetics.  J Allergy Clin Immunol  2004; 114:13.A review on potential use of tyrosine kinase inhibitors based on mutations in KIT Barbie […]

Goldman: Cecil Medicine, 23rd ed. Copyright © 2007 Saunders, An Imprint of Elsevier SUGGESTED READINGS Brooks PM: The burden of musculoskeletal disease—a global perspective.  Clin Rheumatol  2006; 25:778-781.An epidemiologic review Moore G: Atlas of the Musculoskeletal Examination,  Philadelphia, American College of Physicians, 2003. (accessed June 26, 2006). Contains many pictures of joint examination Available at www.acponline.org Thomsen TW, Shen S, Shaffer RW, et al: Videos in […]

Goldman: Cecil Medicine, 23rd ed. Copyright © 2007 Saunders, An Imprint of Elsevier Chapter 276 – MASTOCYTOSIS Cem Akin Definition Mastocytosis is a heterogeneous group of disorders characterized by pathologic accumulation of mast cells in tissues such as skin and bone marrow. According to the classification of the World Health Organization (WHO), based on clinical presentation and pathologic […]

Goldman: Cecil Medicine, 23rd ed. Copyright © 2007 Saunders, An Imprint of Elsevier Chapter 278 – LABORATORY TESTING IN THE RHEUMATIC DISEASES David S. Pisetsky The rheumatic diseases are a heterogeneous group of conditions that result from diverse pathophysiologic mechanisms and involve the musculoskeletal system as well as other organs. These conditions range from mild, diffuse joint and […]

Goldman: Cecil Medicine, 23rd ed. Copyright © 2007 Saunders, An Imprint of Elsevier Section XXII – Rheumatic Disease Chapter 277 – APPROACH TO THE PATIENT WITH RHEUMATIC DISEASE William P. Arend   George V. Lawry Diseases of the musculoskeletal system are common and may be both disabling and costly. This chapter provides an approach to the evaluation of patients with rheumatic diseases by […]

Goldman: Cecil Medicine, 23rd ed. Copyright © 2007 Saunders, An Imprint of Elsevier    REFERENCES 1. Mazumder DNG, De KB, Santra A, et al: Randomized placebo-controlled trial of 2,3-dimercapto-1-propanesulfonate (DMPS) in therapy of chronic arsenicosis due to drinking arsenic-contaminated water.  J Toxicol Clin Toxicol  2001; 39:665-674. 2. Koller WC, Lyons KE, Truly W: Effect of levodopa treatment for parkinsonism in welders: A double-blind study. […]

Goldman: Cecil Medicine, 23rd ed. Copyright © 2007 Saunders, An Imprint of Elsevier SUGGESTED READINGS Bilo BM, Rueff F, Mosbech H, et al: Diagnosis of hymenoptera venom allergy.  Allergy  2005; 60:1339-1349.Discusses the diagnostic approach to patients with a history of a systemic sting reaction Brown SK, Blackman KE, Stenlake V, Heddle RJ: Insect sting anaphylaxis: Prospective evaluation of treatment with intravenous adrenaline and volume resuscitation. […]

Goldman: Cecil Medicine, 23rd ed. Copyright © 2007 Saunders, An Imprint of Elsevier    REFERENCES 1. Premawardhena AP, de Silva CE, Fonseka MM, et al: Low dose subcutaneous epinephrine to prevent acute adverse reactions to antivenom serum in people bitten by snakes: Randomised, placebo-controlled trial.  BMJ  1999; 318:1041-1043. Email to Colleague Print Version Copyright © 2007 Elsevier Inc. All rights reserved. […]

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