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Ovid: Oxford Handbook of Dialysis

Editors: Levy, Jeremy; Morgan, Julie; Brown, Edwina Title: Oxford Handbook of Dialysis, 2nd Edition Copyright ©2004 Oxford University Press > Table of Contents > Part 8 – Complications of ESRD: anaemia > Intravenous iron preparations: iron sucrose Intravenous iron preparations: iron sucrose Iron III hydroxide sucrose complex (iron sucrose or saccharate)

  • Widely used in Europe but only licensed in the US in 2000.
  • Efficacious with a very low incidence of adverse reactions, and no deaths due to anaphylaxis.
  • No need for test dose during first administration.
  • Supplied as 100 mg/5 ml single dose vial.
  • Usual dosing:
    • 100 mg at end of HD on 10 successive dialysis sessions if ferritin <200 ng/ml, then weekly while ferritin <600 ng/ml;
    • 200 mg can be given every 1–3 months in CAPD or predialysis patients as an IV infusion.
  • Can be given as IV infusion or as slow IV injection (at 20 mg/min).
  • Administration protocols:
    • 100–200 mg undiluted over 5–10 min (20 mg/min) is recommended;
    • 100 mg undiluted over 2 min has been reported as being safe;
    • 100 mg in 100 ml N/saline over 15 min.
  • Changes in transferrin saturation and ferritin levels can be measured 48 h after IV administration.

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