UEU-co logo

AccessMedicine – Print

Print   Close Window
Note: Large images and tables on this page may necessitate printing in landscape mode.

Copyright ©2007 The McGraw-Hill Companies.  All rights reserved.

Williams Hematology > Part XI. Transfusion Medicine > Color Atlas XXII: Lymph Node Biopsies >

Lymph Node Biopsies

Plate XXII-1

Normal lymph node.

Plate XXII-2

Normal lymph node.

Plate XXII-3

Reactive lymph node with follicular hyperplasia.

Plate XXII-4

Same reactive lymph node stained with an antibody to CD20 (B cell marker).

Plate XXII-5

Same reactive lymph node stained with an antibody to CD3 (T cell marker).

Plate XXII-6

Same reactive lymph node stained with an antibody to the anti-apoptotic protein Bc1-2. Note the negative staining of the germinal centers where most of the cells will die during the maturation process.

Plate XXII-7

The typical cellular appearance of a benign germinal center.

Plate XXII-8

Lymphoblastic lymphoma of T cell type.

Plate XXII-9

Small lymphocytic lymphoma with vague nodular appearance (pseudo-follicular pattern).

Plate XXII-10

Characteristic nuclear features of small lymphocytic lymphoma.

Plate XXII-11

Imprint preparation of lymphoplasmacytic lymphoma.

Plate XXII-12

Large bowel involved with MCL (multiple lymphomatous polyposis).

Plate XXII-13

Mantle cell lymphoma (MCL) with a diffuse pattern.

Plate XXII-14

Mantle cell lymphoma with a mantle-zone pattern.

Plate XXII-15

MCL with mantle-zone pattern stained with antibody to cyclin D1.

Plate XXII-16

Grade 2 follicular lymphoma (low-power magnification).

Plate XXII-17

Center of a neoplastic follicle in grade 1 follicular lymphoma with almost exclusively small centrocytes.

Plate XXII-18

Grade 3A follicular lymphoma with <15 centroblasts per high-power field.

Plate XXII-19

BCL-2 immunostain of a follicular lymphoma (contrast with Plate XXII-6).

Plate XXII-20

Lymph node involved by marginal zone B cell lymphoma.

Plate XXII-21

Salivary gland involved by MALT lymphoma.

Plate XXII-22

Diffuse large B cell lymphoma.

Plate XXII-23

Diffuse large B cell lymphoma stained with antibody to CD20.

Plate XXII-24

Primary mediastinal large B cell lymphoma with sclerosis.

Plate XXII-25

Burkitt lymphoma with starry-sky appearance.

Plate XXII-26

Burkitt lymphoma.

Plate XXII-27

Peripheral T cell lymphoma, unspecified.

Plate XXII-28

Peripheral T cell lymphoma stained with antibody to CD3.

Plate XXII-29

Anaplastic large cell lymphoma, T cell type.

Plate XXII-30

Anaplastic large cell lymphoma stained with antibody to CD30.

Plate XXII-31

Anaplastic large cell lymphoma stained with antibody to ALK (anaplastic lymphoma kinase).

Plate XXII-32

Diagnostic Reed-Sternberg cell in Hodgkin lymphoma.

Plate XXII-33

Classical Hodgkin lymphoma stained with antibody to CD30.

Plate XXII-34

Classical Hodgkin lymphoma with Reed-Sternberg cells clearly identified with antibody to CD15.

Plate XXII-35

Classical Hodgkin lymphoma, nodular sclerosis type with characteristic lacunar cells.

Plate XXII-36

Mixed cellularity Hodgkin lymphoma.

Plate XXII-37

Nodular lymphocyte predominance Hodgkin lymphoma showing characteristic “L&H cells” (popcorn cells).

Plate XXII-38

Nodular lymphocyte predominance Hodgkin lymphoma stained with antibody to CD20. Note the positive staining of the L & H cells (popcorn cells).

Plate XXII-39

Gene expression profiling of diffuse large B cell lymphoma, showing the subgroup discriminator used to divide cases into germinal center B cell-like (GCB) and activated B cell-like (ABC). Each vertical column represents an individual patient and each horizontal row a unique gene. Red is relative over-expression of a gene and green relative under-expression. Using a probability of subgroup assignment of 90%, approximately 15% of cases are left unclassified (cases between the vertical yellow bars that are neither GCB or ABC). This approach allows one to analyze thousands of genes from a single patient in one experiment, and forms the basis of the new molecular classification of lymphomas.

(Reproduced from Proceedings of the National Academy of Sciences, USA, 2003, 100: pp 9991–9996, by copyright permission of the National Academy of Sciences, USA.)

(See Chap. 95, “Pathology of Malignant Lymphomas.”)

Plate XXII-40

Gene expression profiling of primary mediastinal large B cell lymphoma (PMBCL), contrasting the expression profile with nodal diffuse large B cell lymphomas (DLBCL). This figure shows numerous genes that are over-expressed in PMBCL (red). Many of these genes are shared with classical Hodgkin lymphoma, suggesting a biological overlap between these two diseases. Cases listed as “Other Mediastinal” refer to those cases of DLBCL with mediastinal involvement, but not felt to be typical of PMBCL. This is borne out by the gene expression data, showing that these cases are more closely related to DLBCL rather than PMBCL.

(Reproduced from the Journal of Experimental Medicine, 2003, 198: pp 851–862, by copyright permission of The Rockefeller University Press.)

(See Chap. 95, “Pathology of Malignant Lymphomas.”)

Copyright ©2007 The McGraw-Hill Companies.  All rights reserved.
Privacy Notice. Any use is subject to the Terms of Use and Notice.  Additional Credits and Copyright Information.

McGraw-Hill Education A Silverchair Information System The McGraw-Hill Companies

Leave a Reply


Time limit is exhausted. Please reload the CAPTCHA.

Categories

apply_now Pepperstone Group Limited